Bayesian P-Splines to investigate the impact of covariates on Multiple Sclerosis clinical course

This paper aims at proposing suitable statistical tools to address heterogeneity in repeated measures, within a Multiple Sclerosis (MS) longitudinal study. Indeed, due to unobservable sources of heterogeneity, modelling the effect of covariates on MS severity evolves as a very difficult feature. Bayesian P-Splines are suggested for modelling non linear smooth effects of covariates within generalized additive models. Thus, based on a pooled MS data set, we show how extending Bayesian P-splines to mixed effects models (Lang and Brezger, 2001), represents an attractive statistical approach to investigate the role of prognostic factors in affecting individual change in disability

Phase separation frustrated by the long range Coulomb interaction II: Applications

The theory of first order density-driven phase transitions with frustration due to the long range Coulomb (LRC) interaction develop on paper I of this series is applied to the following physical systems: i) the low density electron gas ii) electronic phase separation in the low density three dimensional $t-J$ model iii) in the manganites near the charge ordered phase. We work in the approximation that the density within each phase is uniform and we assume that the system separates in spherical drops of one phase hosted by the other phase with the distance between drops and the drop radius much larger than the interparticle distance. For i) we study a well known apparent instability related to a negative compressibility at low densities. We show that this does not lead to macroscopic drop formation as one could expect naively and the system is stable from this point of view. For ii) we find that the LRC interaction significantly modifies the phase diagram favoring uniform phases and mixed states of antiferromagnetic (AF) regions surrounded by metallic regions over AF regions surrounded by empty space. For iii) we show that the dependence of local densities of the phases on the overall density found in paper I gives a non-monotonous behavior of the Curie temperature on doping in agreement with experiments.Comment: Second part of cond-mat/0010092 12 pages, 12 figure

Coarse grained models in Coulomb-frustrated phase separation

Competition between interactions on different length scales leads to self-organized textures in classical as well as quantum systems. This pattern formation phenomenon has been invoked to explain some intriguing properties of a large variety of strongly correlated electronic systems that includes for example high temperature superconductors and colossal magnetoresistance manganites. We classify the more common situations in which Coulomb frustrated phase separation can occur and review their properties.Comment: 13 pages, 4 figures. Presented at "Phase Separation in Electronic Systems", Crete 200

Electron-phonon coupling close to a metal-insulator transition in one dimension

We consider a one-dimensional system of electrons interacting via a short-range repulsion and coupled to phonons close to the metal-insulator transition at half filling. We argue that the metal-insulator transition can be described as a standard one dimensional incommensurate to commensurate transition, even if the electronic system is coupled to the lattice distortion. By making use of known results for this transition, we prove that low-momentum phonons do not play any relevant role close to half-filling, unless their coupling to the electrons is large in comparison with the other energy scales present in the problem. In other words the effective strength of the low-momentum transferred electron-phonon coupling does not increase close to the metal-insulator transition, even though the effective velocity of the mobile carriers is strongly diminished.Comment: 20 pages, REVTEX styl

Phase separation frustrated by the long range Coulomb interaction I: Theory

We analyze the combined effect of the long range Coulomb (LRC) interaction and of surface energy on first order density-driven phase transitions in the presence of a compensating rigid background. We study mixed states formed by regions of one phase surrounded by the other in the case in which the scale of the inhomogeneities is much larger than the interparticle distance. Two geometries are studied in detail: spherical drops of one phase into the other and a layered structure of one phase alternating with the other. We find the optimum density profile in an approximation in which the free energy is a functional of the local density (LDA). It is shown that an approximation in which the density is assumed to be uniform (UDA) within each phase region gives results very similar to those of the more involved LDA approach. Within the UDA we derive the general equations for the chemical potential and the pressures of each phase which generalize the Maxwell construction to this situation. The equations are valid for a rather arbitrary geometry. We find that the transition to the mixed state is quite abrupt i.e. inhomogeneities of the first phase appear with a finite value of the radius and of the phase volume fraction. The maximum size of the inhomogeneities is found to be on the scale of a few electric field screening lengths. Contrary to the ordinary Maxwell construction, the inverse specific volume of each phase depends here on the global density in the coexistence region and can decrease as the global density increases. The range of densities in which coexistence is observed shrinks as the LRC interaction increases until it reduces to a singular point. We argue that close to this singular point the system undergoes a lattice instability as long as the inverse lattice compressibility is finite.Comment: 17 pages, 14 figures. We added a section were the density profile of inhomogeneities is arbitrary and included other geometries. The applications of the original version are in a separate pape

A Generating Function for Fatgraphs

We study a generating function for the sum over fatgraphs with specified valences of vertices and faces, inversely weighted by the order of their symmetry group. A compact expression is found for general (i.e. non necessarily connected) fatgraphs. This expression admits a matrix integral representation which enables to perform semi--classical computations, leading in particular to a closed formula corresponding to (genus zero, connected) trees.Comment: 24 pages, uses harvmac macro, 1 figure not included, Saclay preprint SPhT/92-16

Luttinger liquid, singular interaction and quantum criticality in cuprate materials

With particular reference to the role of the renormalization group approach and Ward identities, we start by recalling some old features of the one-dimensional Luttinger liquid as the prototype of non-Fermi-liquid behavior. Its dimensional crossover to the Landau normal Fermi liquid implies that a non-Fermi liquid, as, e.g., the normal phase of the cuprate high temperature superconductors, can be maintained in d>1, only in the presence of a sufficiently singular effective interaction among the charge carriers. This is the case when, nearby an instability, the interaction is mediated by fluctuations. We are then led to introduce the specific case of superconductivity in cuprates as an example of avoided quantum criticality. We will disentangle the fluctuations which act as mediators of singular electron-electron interaction, enlightening the possible order competing with superconductivity and a mechanism for the non-Fermi-liquid behavior of the metallic phase. This paper is not meant to be a comprehensive review. Many important contributions will not be considered. We will also avoid using extensive technicalities and making full calculations for which we refer to the original papers and to the many good available reviews. We will here only follow one line of reasoning which guided our research activity in this field.Comment: 23 pages, 10 figure

Anti-transpirant effects on vine physiology, berry and wine composition of cv. Aglianico (Vitis vinifera L.) Grown in South Italy

In viticulture, global warming requires reconsideration of current production models. At the base of this need there are some emerging phenomena: modification of phenological phases; acceleration of the maturation process of grapes, with significant increases in the concentration of sugar musts; decoupling between technological grape maturity and phenolic maturity. The aim of our study was to evaluate the effect of a natural anti-transpirant on grapevine physiology, berry, and wine composition of Aglianico cultivar. For two years, Aglianico vines were treated at veraison with the anti-transpirant Vapor Gard and compared with a control sprayed with only water. A bunch thinning was also applied to both treatments. The effectiveness of Vapor Gard were assessed through measurements of net photosynthesis and transpiration and analyzing the vegetative, productive and qualitative parameters. The results demonstrate that the application of antitranspirant reduced assimilation and transpiration rate, stomatal conductance, berry sugar accumulation, and wine alcohol content. No significant differences between treatments were observed for other berry and wine compositional parameters. This method may be a useful tool to reduce berry sugar content and to produce wines with a lower alcohol content